生物活性

Gefitinib (Iressa)是一种EGFR抑制剂，可阻断靶细胞中表皮生长因子受体(EGFR)的信号传导。

靶点信息

Tyr1173 (NR6W cells)	Tyr1173 (NR6wtEGFR cells)	Tyr992 (NR6wtEGFR cells)	Tyr992 (NR6W cells)
26 nM	37 nM	37 nM	57 nM

化学数据

目录号	A10422
作用机制	Inhibitor (抑制剂)
M. Wt	446.9
Formula	C22H24ClFN4O3
Purity	>99%
Storage	Store lyophilized at -20?C, keep desiccated. In lyophilized form, the chemical is stable for36 months. In solution, store at -20?C and use within3 monthsto prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.
CAS No.	184475-35-2
Synonyms	ZD-1839
SMILES	COC1=C(C=C2C(=C1)N=CN=C2NC3=CC(=C(C=C3)F)Cl)OCCCN4CCOCC4

溶解度

In vitro (25°C)	DMSO	80 mg/mL (179 mM)
	Water	Insoluble
	Ethanol	4 mg/mL (8.95 mM)
In vivo	1% CMC Na	28 mg/mL
*<1 mg/ml means slightly soluble or insoluble. *Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

储备液配制

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	22.38 mL	111.88 mL	223.76 mL
0.5 mM	4.48 mL	22.38 mL	44.75 mL
1 mM	2.24 mL	11.19 mL	22.38 mL
5 mM	0.45 mL	2.24 mL	4.48 mL

*The above data is based on the productmolecular weight 446.9 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.