生物活性

FTY720 (Fingolimod)是ISP-1(肉豆蔻酸)的衍生物，ISP-1是中国草药Iscaria sinclarii的真菌代谢物，也是鞘氨醇的结构类似物。

靶点信息

S1P receptor (K562, NK cells )
0.033 nM

化学数据

目录号	A10408
作用机制	Antagonist (拮抗剂)
M. Wt	343.9
Formula	C19H33NO2.HCl
Purity	>99%
Storage	Store lyophilized at -20?C, keep desiccated. In lyophilized form, the chemical is stable for36 months. In solution, store at -20?C and use within3 monthsto prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.
CAS No.	162359-56-0
Synonyms	Gilenia
SMILES	CCCCCCCCC1=CC=C(C=C1)CCC(CO)(CO)N.Cl

溶解度

In vitro (25°C)	DMSO	64 mg/mL (186.09 mM)
	Water	64 mg/mL (186.09 mM)
	Ethanol	64 mg/mL (186.09 mM)
In vivo	Saline	19 mg/mL
*<1 mg/ml means slightly soluble or insoluble. *Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

储备液配制

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	29.08 mL	145.39 mL	290.78 mL
0.5 mM	5.82 mL	29.08 mL	58.16 mL
1 mM	2.91 mL	14.54 mL	29.08 mL
5 mM	0.58 mL	2.91 mL	5.82 mL

*The above data is based on the productmolecular weight 343.9 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.