生物活性

Elvitegravir (GS-9137)是一种有效的抑制剂，可抑制人类1型免疫缺陷病毒（HIV-1）整合酶介导的整合链转移步骤。

靶点信息

HIV-1 IIIB (Cell-free assay)	HIV-2 ROD (Cell-free assay)	HIV-2 EHO (Cell-free assay)
0.7 nM	1.4 nM	2.8 nM

化学数据

目录号	A10347
作用机制	Inhibitor (抑制剂)
M. Wt	447.9
Formula	C23H23ClFNO5
Purity	>99%
Storage	Store lyophilized at -20?C, keep desiccated. In lyophilized form, the chemical is stable for36 months. In solution, store at -20?C and use within3 monthsto prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.
CAS No.	697761-98-1
Synonyms	GS9137
SMILES	CC(C)[C@@H](CO)N1C=C(C(=O)C2=CC(=C(C=C21)OC)CC3=C(C(=CC=C3)Cl)F)C(=O)O

溶解度

In vitro	DMSO	85 mg/mL (189.78 mM)
	Water	Insoluble
	Ethanol	33 mg/mL (73.67 mM)
*<1 mg/ml means slightly soluble or insoluble. *Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

储备液配制

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	22.33 mL	111.63 mL	223.26 mL
0.5 mM	4.47 mL	22.33 mL	44.65 mL
1 mM	2.23 mL	11.16 mL	22.33 mL
5 mM	0.45 mL	2.23 mL	4.47 mL

*The above data is based on the productmolecular weight 447.9. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.