生物活性
Chelerythrine Chloride是一种有效的，选择性的PKC拮抗剂， IC50为0.66 μM。影响PKC从细胞质到质膜的转运。显示可防止神经突生长。以浓度和时间表依赖性方式诱导凋亡。
化学数据
| 目录号 |
A10196 |
| 作用机制 |
Inhibitor (抑制剂) |
| M. Wt |
383.8 |
| Formula |
C21H18ClNO4 |
| Purity |
>99% |
| Storage |
Store lyophilized at -20?C, keep desiccated.
In lyophilized form, the chemical is stable for36 months.
In solution, store at -20?C and use within3 monthsto prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles. |
| CAS No. |
3895-92-9 |
| SMILES |
C[N+]1=C2C(=C3C=CC(=C(C3=C1)OC)OC)C=CC4=CC5=C(C=C42)OCO5.[Cl-] |
溶解度
| In vitro |
DMSO |
3 mg/mL (7.79 mM) |
| Water |
Insoluble |
| Ethanol |
Insoluble |
*<1 mg/ml means slightly soluble or insoluble.
*Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
储备液配制
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 0.1 mM |
26.06 mL |
130.28 mL |
260.55 mL |
| 0.5 mM |
5.21 mL |
26.06 mL |
52.11 mL |
| 1 mM |
2.61 mL |
13.03 mL |
26.06 mL |
| 5 mM |
0.52 mL |
2.61 mL |
5.21 mL |
*The above data is based on the productmolecular weight 383.8 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
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