生物活性

Celastrol是一种有效的蛋白酶抑制剂，有效且优先抑制胰凝乳蛋白酶样的纯化的20S proteasome的活性，IC50为2.5 μM。

靶点信息

20S proteasome	20S proteasome
N/A	2.5 μM

化学数据

目录号	A10192
M. Wt	450.6
Formula	C29H38O4
Purity	>99%
Storage	Store lyophilized at -20?C, keep desiccated. In lyophilized form, the chemical is stable for36 months. In solution, store at -20?C and use within3 monthsto prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.
CAS No.	34157-83-0
SMILES	CC1=C(C(=O)C=C2C1=CC=C3[C@]2(CC[C@@]4([C@@]3(CC[C@@]5([C@H]4C[C@](CC5)(C)C(=O)O)C)C)C)C)O

溶解度

In vitro	DMSO	82 mg/mL (181.97 mM)
	Water	Insoluble
	Ethanol	Insoluble
*<1 mg/ml means slightly soluble or insoluble. *Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

储备液配制

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	22.19 mL	110.96 mL	221.93 mL
0.5 mM	4.44 mL	22.19 mL	44.39 mL
1 mM	2.22 mL	11.1 mL	22.19 mL
5 mM	0.44 mL	2.22 mL	4.44 mL

*The above data is based on the productmolecular weight 450.6 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.