生物活性

CAL-101 (GS-1101,Idelalisib)是PI3K的同种型选择性抑制剂，可诱导慢性淋巴细胞性白血病（CLL）细胞凋亡。

Targets

Target	Value
p110δ	IC50: 2.5nM
p110γ	IC50: 89nM
p110β	IC50: 565nM
p110α	IC50: 820nM
hVps34	IC50: 978nM
C2β	IC50: >1μM
mTOR	IC50: >1μM
PIP5Kα	IC50: >1μM
PIP5Kβ	IC50: >1μM
DNA-PK	IC50: 6.729μM

化学数据

目录号	A10172
作用机制	Inhibitor (抑制剂)
M. Wt	415.4
Formula	C22H18FN7O
Purity	>99%
Storage	Store lyophilized at -20?C, keep desiccated. In lyophilized form, the chemical is stable for36 months. In solution, store at -20?C and use within3 monthsto prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.
CAS No.	870281-82-6
Synonyms	CAL101
SMILES	CC[C@@H](C1=NC2=C(C(=CC=C2)F)C(=O)N1C3=CC=CC=C3)NC4=NC=NC5=C4NC=N5

溶解度

In vitro (25°C)	DMSO	Warmed: 76 mg/mL (182.94 mM)
	Water	Insoluble
	Ethanol	21 mg/mL (50.55 mM)
In vivo	2% DMSO+20%PEG 300+ddH2O	4 mg/mL
*<1 mg/ml means slightly soluble or insoluble. *Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

储备液配制

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	24.07 mL	120.37 mL	240.73 mL
0.5 mM	4.81 mL	24.07 mL	48.15 mL
1 mM	2.41 mL	12.04 mL	24.07 mL
5 mM	0.48 mL	2.41 mL	4.81 mL

*The above data is based on the productmolecular weight 415.4 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.