P516-0475 is a novel chemical inducer of Streptococcus quorum sensing acts by inhibiting the pheromone-degrading endopeptidase PepO. This compound induces quorum sensing by stabilizing SHP pheromones in culture. References: Pérez Morales TG, Ratia K, Wang DS, Gogos A, Bloem L, Driver TG, Federle MJ. A novel chemical inducer of Streptococcus quorum sensing acts by inhibiting the pheromone-degrading endopeptidase PepO. J Biol Chem. 2018 Jan 19;293(3):931-940. doi: 10.1074/jbc.M117.810994. Epub 2017 Dec 4. Erratum in: J Biol Chem. 2018 Mar 23;293(12 ):4580. Bloem, Laura [author added];. PubMed PMID: 29203527; PubMed Central PMCID: PMC5777264.
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CAS:1359627-33-0