生物活性

EHT 1864是一种抑制Rac家族GTPases的抗增殖化学物质。

靶点信息

Rac1	Rac1b	Rac2	Rac3
40 nM(Kd)	50 nM(Kd)	60 nM(Kd)	250 nM(Kd)

化学数据

目录号	A13886
作用机制	Inhibitor (抑制剂)
M. Wt	581.47
Formula	C25H27F3N2O4S.2HCl
Purity	>99%
Storage	Store lyophilized at -20?C, keep desiccated. In lyophilized form, the chemical is stable for36 months. In solution, store at -20?C and use within3 monthsto prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.
CAS No.	754240-09-0
Synonyms	EHT-1864, EHT1864
SMILES	C1COCCN1CC2=CC(=O)C(=CO2)OCCCCCSC3=C4C=CC(=CC4=NC=C3)C(F)(F)F.Cl.Cl

溶解度

In vitro	DMSO	Warmed: 90 mg/mL (154.77 mM)
	Water	90 mg/mL (154.77 mM)
	Ethanol	Insoluble
*<1 mg/ml means slightly soluble or insoluble. *Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

储备液配制

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	17.2 mL	85.99 mL	171.98 mL
0.5 mM	3.44 mL	17.2 mL	34.4 mL
1 mM	1.72 mL	8.6 mL	17.2 mL
5 mM	0.34 mL	1.72 mL	3.44 mL

*The above data is based on the productmolecular weight 581.47. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.