生物活性

GS-9973 (Entospletinib)是一种口服酪氨酸激酶（Syk）抑制剂，具有潜在的抗肿瘤活性。

靶点信息

Syk (Cell-free assay)
7.7 nM

化学数据

目录号	A13884
作用机制	Inhibitor (抑制剂)
M. Wt	411.46
Formula	C23H21N7O
Purity	>99%
Storage	Store lyophilized at -20?C, keep desiccated. In lyophilized form, the chemical is stable for36 months. In solution, store at -20?C and use within3 monthsto prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.
CAS No.	1229208-44-9
Synonyms	GS9973, GS 9973, Entospletinib
SMILES	C1COCCN1C2=CC=C(C=C2)NC3=NC(=CN4C3=NC=C4)C5=CC6=C(C=C5)C=NN6

溶解度

In vitro (25°C)	DMSO	Warmed: 26 mg/mL (63.18 mM)
	Water	Insoluble
	Ethanol	Insoluble
In vivo	4% DMSO+30% PEG 300+5% Tween 80+ddH2O	2.3 mg/mL
*<1 mg/ml means slightly soluble or insoluble. *Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

储备液配制

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	24.3 mL	121.52 mL	243.04 mL
0.5 mM	4.86 mL	24.3 mL	48.61 mL
1 mM	2.43 mL	12.15 mL	24.3 mL
5 mM	0.49 mL	2.43 mL	4.86 mL

*The above data is based on the productmolecular weight 411.46. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.