NWL-117 is an irreversible (covalent) caspase inhibitor. NWL-117 exhibits a higher selectivity against Caspase-6, -4, -8, -9, and -10. References: Pakavathkumar P, Noel A, Lecrux C, Tubeleviciute-Aydin A, Hamel E, Ahlfors JE, LeBlanc AC. Caspase vinyl sulfone small molecule inhibitors prevent axonal degeneration in human neurons and reverse cognitive impairment in Caspase-6-overexpressing mice. Mol Neurodegener. 2017 Feb 28;12(1):22. doi: 10.1186/s13024-017-0166-z. PubMed PMID: 28241839; PubMed Central PMCID: PMC5329948.
纯度:≥98%