生物活性

GNE-7915是一种富含亮氨酸重复激酶2（LRRK2）的血脑屏障（BBB）渗透性小分子抑制剂。

靶点信息

LRRK2	LRRK2
1 nM(Ki)	9 nM

化学数据

目录号	A13748
作用机制	Inhibitor (抑制剂)
M. Wt	443.395
Formula	C19H21F4N5O3
Purity	>99%
Storage	Store lyophilized at -20?C, keep desiccated. In lyophilized form, the chemical is stable for36 months. In solution, store at -20?C and use within3 monthsto prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.
CAS No.	1351761-44-8
Synonyms	GNE7915, GMS 7915
SMILES	CCNC1=NC(=NC=C1C(F)(F)F)NC2=C(C=C(C(=C2)F)C(=O)N3CCOCC3)OC

溶解度

In vitro (25°C)	DMSO	Warmed: 21 mg/mL (47.36 mM)
	Water	Insoluble
	Ethanol	Insoluble
In vivo	5% DMSO+30% PEG 300+5% Tween 80+ddH2O	2.9 mg/mL
*<1 mg/ml means slightly soluble or insoluble. *Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

储备液配制

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	22.55 mL	112.77 mL	225.53 mL
0.5 mM	4.51 mL	22.55 mL	45.11 mL
1 mM	2.26 mL	11.28 mL	22.55 mL
5 mM	0.45 mL	2.26 mL	4.51 mL

*The above data is based on the productmolecular weight 443.395. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.