STING agonist-3, compound 3, is a selective and non-nucleotide small-molecule STING agonist, which has durable anti-tumor effect and tremendous potential to improve treatment of cancer. STING agonist-3 induces activation of STING and secretion of IFN-β with ECapp50 values of 130 nM, 186 nM in human PBMCs and Mouse PBMCs. References: Ramanjulu JM et al. Design of amidobenzimidazole STING receptor agonists with systemic activity. Nature. 2018 Dec;564(7736):439-443.
纯度:≥98%
CAS:2138299-29-1