生物活性

Lomeguatrib是O6-烷基鸟嘌呤-DNA-烷基转移酶的有效抑制剂。

靶点信息

O6-alkylguanine-DNA-alkyltransferas
5 nM

化学数据

目录号	A12785
作用机制	Inhibitor (抑制剂)
M. Wt	326.17
Formula	C10H8BrN5OS
Purity	>99%
Storage	Store lyophilized at -20?C, keep desiccated. In lyophilized form, the chemical is stable for36 months. In solution, store at -20?C and use within3 monthsto prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.
CAS No.	192441-08-0
Synonyms	O6-(4-bromothenyl)guanine
SMILES	C1=C(SC=C1Br)COC2=NC(=NC3=C2NC=N3)N

溶解度

In vitro	DMSO	60 mg/mL (183.95 mM)
	Water	Insoluble
	Ethanol	Insoluble
*<1 mg/ml means slightly soluble or insoluble. *Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

储备液配制

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	30.66 mL	153.29 mL	306.59 mL
0.5 mM	6.13 mL	30.66 mL	61.32 mL
1 mM	3.07 mL	15.33 mL	30.66 mL
5 mM	0.61 mL	3.07 mL	6.13 mL

*The above data is based on the productmolecular weight 326.17. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.