is a parenteral, potential best-in-class, reversible, specific boronic acid-containing compound that inhibits both serine- and metallo-β-lactamases with IC50s of 8-530 nM. Combined with cefepime, a fourth generation cephalosporin antibiotic, taniborbactam drives antimicrobial activity against gram-negative bacteria that have acquired multi-drug resistance (MDR) via classes A, B, C and D β-lactamase expression. Taniborbactam is the only known β-lactamase inhibitor in advanced clinical development that blocks class B carbapenemases. In 2019, Everest Medicines and licensing partner Venatorx Pharmaceuticals initiated a global Phase 3 clinical trial for patients with complicated urinary tract infections (cUTI).