生物活性
Icilin是一种冷却剂，可激活新型的冷受体TRPM8（CMR1）和TRPA1（ANKTM1/TRPN1），它们是TRP离子通道家族的成员。在表达CMR1的HEK 293细胞中感应电流（EC50 = 0.36μM）。
化学数据
| 目录号 |
A13560 |
| 作用机制 |
Activator (激活剂) |
| M. Wt |
311.3 |
| Formula |
C16H13N3O4 |
| Purity |
>99% |
| Storage |
Store lyophilized at -20?C, keep desiccated.
In lyophilized form, the chemical is stable for36 months.
In solution, store at -20?C and use within3 monthsto prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles. |
| CAS No. |
36945-98-9 |
| Synonyms |
AG 3-5 |
| SMILES |
C1C=C(NC(=O)N1C2=CC=CC=C2O)C3=CC(=CC=C3)[N+](=O)[O-] |
储备液配制
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 0.1 mM |
32.12 mL |
160.62 mL |
321.23 mL |
| 0.5 mM |
6.42 mL |
32.12 mL |
64.25 mL |
| 1 mM |
3.21 mL |
16.06 mL |
32.12 mL |
| 5 mM |
0.64 mL |
3.21 mL |
6.42 mL |
*The above data is based on the productmolecular weight 311.3. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
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