Endogenous central calcitonin (CT) receptor agonist that stimulates cAMP formation at a potency 350-fold greater than CT (ED50 values are 0.2 and 71 nM respectively). Displays no activity at calcitonin-gene related peptide (CGRP) and adrenomedullin receptors. Inhibits formation of multinuclear osteoclasts with similar efficacy to CT in vitro. Suppresses food intake and increases body temperature in free-feeding rats, and significantly decreases plasma calcium levels in vivo.

697327-12-1

C175H294N54O49S5

4098.88

CRSP-1

10% acetonitrile / water:0.50 mg/mL
Powder: -20°C for 3 years
In solvent: -80°C for 2 years