Meropenem是一种具有广谱抗菌活性的碳青霉烯抗生素，对敏感和耐药的淋病奈瑟氏球菌，流感嗜血杆菌和杜克氏杆菌的 MIC 值分别为 0.02-0.06 mg/mL，0.03-0.12 mg/mL 和 0.015-0.12 mg/mL。

Meropenem is a carbapenem antibiotic with broad spectrum of activity that is administered intravenously and used for severe bacterial infections due to sensitive agents. Meropenem is a common cause of mild transient aminotransferase elevations and can rarely result in clinically apparent, cholestatic liver injury.

Meropenem明显提高兔体内丙戊酸-葡萄糖醛酸在尿中的排泄.

Meropenem具有类似于亚胺培南的抗菌谱,但对葡萄状球菌和肠球菌的活性略低,它对绿脓杆菌、所有的肠杆菌科和流感嗜血杆菌具有更强的活性。Meropenem对革兰氏阴性生物体的抗微生物活性是亚胺培南的两到四倍,其抗菌谱比测试的所有其他药物更宽。Meropenem与其他几个β-内酰胺类抗株产I型头孢菌素有拮抗效应。Meropenem最强烈地结合大肠杆菌和绿脓杆菌的青霉素结合蛋白2和金黄色葡萄球菌的青霉素结合蛋白1。

Complementation of SCR7 Inhibition with Puri?ed Ligase IV: Complementation experiment is carried out by adding increasing concentrations of puri?ed Ligase IV/XRCC4 complex (30, 60, and 120 fmol) along with the oligomeric DNA substrates (5' compatible and 5'-5' noncompatible ends) to the SCR7-treatedextracts. Reactions are incubated for 2 h at 25℃. The reaction products are then resolved on 8% denaturing PAGE. The gel is dried and exposed and the signal is detected with a PhosphorImager and analyzed with Multi Gauge (V3.0) software.

96036-03-2

C17H25N3O5S

383.46

SM 7338;美罗培南;Meropenem

DMSO:71 mg/mL (185.2 mM)
Ethanol:<1 mgml
H2O:8 mg/mL (20.86 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years