In addition to its role in the Krebs cycle, α-ketoglutarate (2-oxoglutarate) has roles as a substrate or modulator of enzymes. 5-Octyl-α-ketoglutarate, also known as α-ketoglutarate octyl ester, is a stable, cell-permeable molecule that generates free α-ketoglutarate upon hydrolysis of the ester bond by cytoplasmic esterases. It is used in experiments to increase levels of intracellular α-ketoglutarate. 5-Octyl-α-ketoglutarate has been shown to modulate a variety of enzymes and signaling pathways, particularly in the context of glycolysis, hypoxia, and cancer.

1616344-00-3

C13H22O5

258.31

5-Octyl-α-ketoglutarate

DMSO:10 mg/mL
Ethanol:20 mg/mL
PBS (pH 7.2):1 mg/mL
DMF:10 mg/mL
Powder: -20°C for 3 years
In solvent: -80°C for 2 years