(R)-(-)-Ibuprofen 是 Ibuprofen 的 R 型异构体，对 COX 无作用，可以抑制 NF-Κb 的活化；(R)-(-)-Ibuprofen 具有抗炎作用，可用于缓解疼痛的研究。

(R)-(-)-Ibuprofen is the R enantiomer of Ibuprofen and inhibits NF-κB activation. (R)-(-)-Ibuprofen has anti-inflammatory and antinociceptive effects.

(R)-(-)-Ibuprofen is involved in pathways of lipid metabolism and is incorporated into triglycerides along with endogenous fatty acids. (R)-(-)-Ibuprofen inhibits NF-κB luciferase activity (IC50: 121.8 μM), weaker than that of S(+)-ibuprofen (IC50, 61.7 μM). (R)-(-)-Ibuprofen (1 μM) significantly decreases NF-κB activation and fully prevents NF-κB induction at 10 μM. Furthermore, (R)-(-)-Ibuprofen (10 mM) has no effect on HSF [1][2].

51146-57-7

C13H18O2

206.28

levibuprofen;(R)-Ibuprofen;(R)-(-)-Ibuprofen

(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years