VIP(6-28)(human, rat, porcine, bovine) acetate 是外源性血管活性肠肽 (VIP) 受体对颈上神经节 (SCG) 中 cAMP 作用的拮抗剂。

VIP(6-28)(human, rat, porcine, bovine) acetate is an antagonist of the actions of exogenous vasoactive intestinal peptide (VIP) receptor on cAMP in the superior cervical ganglion (SCG).

VIP(6-28)(human, rat, porcine, bovine) acetate (10, 30, or 100 μM) reduces the increase in cAMP levels produced by stimulation with 10 μM VIP by 52, 64, or 81%, respectively. Similar results on the ability of VIP(6-28)(human, rat, porcine, bovine) acetate to block VIP-stimulated increases in cAMP levels are obtained in neuron-enriched and non-neuronal cell-enriched dissociated cultures. At any of these concentrations tested, VIP(6-28)(human, rat, porcine, bovine) acetate by itself does not alter cAMP levels. In contrast to its ability to reduce the VIP-stimulated elevation in cAMP levels by 64%, the addition of 30 μM VIP(6-28)(human, rat, porcine, bovine) acetate to the culture medium does not significantly alter cAMP levels measured after stimulation of adult ganglia with either isoproterenol or forskolin (10 μM each)[1].

TP1283L

C128H211N37O36S

2876.34

VIP(6-28)(human, rat, porcine, bovine) acetate

(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years