TMRM Perchlorate 是细胞渗透性的阳离子亲脂性红色荧光染料 (λex=530 nm, λem=592 nm)。

TMRM Perchlorate is a cell-permeant cationic lipophilic red fluorescent dye (λex=530 nm, λem=592 nm).

TMRM Perchlorate is a fluorescent probe (excitation, 530±21 nm; emission, 592±22 nm). The fluorescence signal in the presence of TMRM Perchlorate shows a slight decrease after the addition of glutamate, indicative of increased polarization of the mitochondrial inner membrane. In the presence of TMRM Perchlorate (2 μM) the coupled respiration with Complex I substrates or upon the addition of Complex II substrate is decreased by 27%[1]. Exposure of hippocampal cultures to low concentrations of TMRM Perchlorate (50 to 500 nM) for 1 to 3 hours results in selective staining of mitochondria in both neurons and the underlying glial cells. Exposure of hippocampal cultures to high concentrations of TMRM Perchlorate (1 to 25 μM) stains mitochondria selectively and quickly, reaching a plateau after 5 to 10 min. Low concentrations of TMRM Perchlorate (50 to 200 nM) do not induce apoptosis, whereas higher concentrations (0.5 and 2.5 μM) enhance apoptosis (KD?=?500 nM)[2].

115532-50-8

C25H25ClN2O7

500.93

四甲基若丹明甲酯酸铵;T668;TMRM Perchlorate

DMSO:41.67 mg/mL (83.19 mM),Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years