生物活性
JAK Inhibitor I 是JAK1、JAK2和JAK3的一种高效、可逆、细胞通透性和ATP竞争性抑制剂。
化学数据
| 目录号 |
A13457 |
| 作用机制 |
Inhibitor (抑制剂) |
| M. Wt |
309.3 |
| Formula |
C18H16FN3O |
| Purity |
>99% |
| Storage |
Store lyophilized at -20?C, keep desiccated.
In lyophilized form, the chemical is stable for36 months.
In solution, store at -20?C and use within3 monthsto prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles. |
| CAS No. |
457081-03-7 |
| Synonyms |
Merck-5,Pyridone 6,DBI |
| SMILES |
CC(C)(C)C1=NC2=C(N1)C3=C(C=C(C=C3)F)C4=C2C=CNC4=O |
储备液配制
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 0.1 mM |
32.33 mL |
161.66 mL |
323.31 mL |
| 0.5 mM |
6.47 mL |
32.33 mL |
64.66 mL |
| 1 mM |
3.23 mL |
16.17 mL |
32.33 mL |
| 5 mM |
0.65 mL |
3.23 mL |
6.47 mL |
*The above data is based on the productmolecular weight 309.3. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
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