LRRK2-IN-4 是一种有效的、选择性的、可透过血脑屏障和具有口服活性的富含亮氨酸的重复激酶 2 (LRRK2) 抑制剂，其IC50值为2.6 nM。LRRK2-IN-4 具有研究帕金森病的潜力。

LRRK2-IN-4 is a potent, selective, CNS-penetran and orally active leucine-rich repeat kinase 2 (LRRK2) inhobitor with an IC 50 of 2.6 nM. LRRK2-IN-4 has the potential for the research of Parkinson’s disease [1].

LRRK2-IN-4 (compound 24) (p.o.) shows good oral bioavailability in male Wistar-Han rats (F=64%), male beagle dogs (F=65%) [1].

2641054-59-1

C25H29ClF2N6O2

518.99

(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years