4-Hydroxynonenal 是一种 α，β 不饱和羟基烯醛，可作为氧化/亚硝化应激生物标志物。它是ALDH2的底物和抑制剂。它可以调节许多信号传导过程，主要是通过与蛋白质，核酸和膜脂质中具有亲核官能团的共价加合物形成的。它通过线粒体在癌症中起重要作用。

4-Hydroxynonenal (4-HNE) is an oxidative/nitrosative stress biomarker. It is a substrate and an inhibitor of acetaldehyde dehydrogenase 2 (ALDH2).

4-Hydroxynonenal is both a substrate and an inhibitor of ALDH2; inhibition of ALDH2 by 4-Hydroxynonenal is reversible at low concentration and becomes irreversible when the concentration of 4-HNE reaches 10 μM. 4-Hydroxynonenal can induce antioxidant defense mechanisms to restrain its own production and to enhance cellular protection against oxidative stress. 4-Hydroxynonenal, the product of lipid peroxidation, is mutagenic and genotoxic in viruses, bacteria, and mammalian cells. It reacts with all four DNA bases but with different efficiency: G >C >A >T. 4-Hydroxynonenal-dG represents the best biomarker of the genotoxic effects of 4-Hydroxynonenal and these adducts are primarily found in nuclear DNA [1].

Following 24 h after fluid percussion injury (FPI), the mouse brain tissue is analyzed for the expression level of NADPH oxidase 1 (NOX1), inducible nitric oxide synthase (iNOS), 4-Hydroxynonenal (4-HNE. Both wild-type (Nrf2+/+) and Nrf2-deficient mice (Nrf2?/?) results in increased expression of 4-Hydroxynonenal following 15 psi injury (moderate injury) when compared to uninjured Nrf2+/+ and Nrf2?/? mice. Similar to the iNOS result, in Nrf2?/? KO mice, the expression level of 4-Hydroxynonenal is significantly high when compared to corresponding injured and uninjured Nrf2+/+ WT animals [2].

75899-68-2

C9H16O2

156.22

4-HNE;4-羟基壬烯醛;4-Hydroxynonenal

DMSO:249 mg/mL(1593.91 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years