| CAS NO: | 141625-93-6 |
| 规格: | ≥98% |
| 包装 | 价格(元) |
| 25mg | 电议 |
| 50mg | 电议 |
| 100mg | 电议 |
| 250mg | 电议 |
| 500mg | 电议 |
| 1g | 电议 |
| Molecular Weight (MW) | 593.22 |
|---|---|
| Formula | C31H44N2O5S.HCl |
| CAS No. | 141625-93-6 |
| Storage | -20℃ for 3 years in powder form |
| -80℃ for 2 years in solvent | |
| Solubility(In vitro) | DMSO: 80 mg/mL (134.9 mM) |
| Water: <1 mg/mL | |
| Ethanol: 40 mg/mL (67.4 mM) | |
| Other info | Chemical Name: N-[2-butyl-3-[4-[3-(dibutylamino)propoxy]benzoyl]-1-benzofuran-5-yl]methanesulfonamide;hydrochloride InChi Key: DWKVCQXJYURSIQ-UHFFFAOYSA-N InChi Code: InChI=1S/C31H44N2O5S.ClH/c1-5-8-12-29-30(27-23-25(32-39(4,35)36)15-18-28(27)38-29)31(34)24-13-16-26(17-14-24)37-22-11-21-33(19-9-6-2)20-10-7-3;/h13-18,23,32H,5-12,19-22H2,1-4H3;1H SMILES Code: CCCCC1=C(C2=C(O1)C=CC(=C2)NS(=O)(=O)C)C(=O)C3=CC=C(C=C3)OCCCN(CCCC)CCCC.Cl |
| Synonyms | SR 33589; SR33589; Dronedarone Hydrochloride; 4CH-007232; SR-33589; D4689; W3083; D03914; S-7529; MCULE-2160502046; RL01735; RTC-070901; AK-72887; BC201083; BR-72887; HY-75839; KB-76727; AB2000517; ST2413542; Dronedarone HCl; UNII-FA36DV299Q |
| In Vitro | In vitroactivity: Dronedarone reduces the incidence of early and delayed after depolarizations evoked by 1 mM Dofetilide and 0.2 mM Strophantidine in Purkinje fibres. Dronedarone (10 mM) markedly reduces the L-type calcium current (76.5%) and the rapid component of the delayed rectifier potassium current (97%) in ventricular myocytes. Dronedarone inhibits the activity of I(K(ACh)) channels recorded from cell-attached patches by reducing the channel open probability (from 0.56 to 0.11) without modification of the single-channel conductance in single cells isolated from sinoatrial node (SAN) tissue of rabbit hearts. Dronedarone exhibits a state-dependent inhibition of the fast Na(+) channel current with an IC50 of 0.7 μM in guinea pig ventricular myocytes, when the holding potential (V (hold)) is -80 mV. Dronedarone blocks Ca(2+) currents elicited by rectangular pulses at V (hold) = -40 mV with IC50 value of 0.4 μM, whereas at V (hold) = -80 mV, Dronedarone (10 μM) blocks only 20 % of the current. |
|---|---|
| In Vivo | Dronedarone increases action potential duration in normal hearts of rats. Dronedarone reduces the late sustained K(+) current, I(K) (or Isus) by 69%. Dronedarone induces only a tonic block of I(K). Dronedarone induces a weak increase in the fast transient outward current, I(to), in rats after myocardial infarction. |
| Animal model | Rats |
| Formulation & Dosage | |
| References | Br J Pharmacol. 2001 Jul;133(5):625-34; Br J Pharmacol. 2001 Jul;133(5):625-34; J Pharmacol Exp Ther. 2000 Jan;292(1):415-24. |
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