BODIPY FL prazosin 是一种荧光 α1-肾上腺素α1-adrenergic拮抗剂,对 α1a-AR 和 α1b-AR 的Ki值分别为 14.5、43.3 nM. BODIPY FL prazosin 也是一种荧光配体,激发和发射波长分别为 485 和 535 nm。BODIPY FL prazosin 可用于研究 α1 -肾上腺素受体亚型的亚细胞定位差异 。
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BODIPY FL prazosin is a fluorescent α1-adrenergic antagonist with K i values of 14.5, 43.3 nM for α1a-AR and α1b-AR, respectively. BODIPY FL prazosin also is a fluorescent ligand with the excitation and emission wavelengths are 485 and 535 nm, respectively. BODIPY FL prazosin can be used for study the differences in the subcellular localization of α1-adrenoceptor subtypes [1] [2] [3].
体外活性
BODIPY FL prazosin (10 nM; 30 min at room temperature in 100 μl; COS-7 cells) shows Affinity of various α1-AR ligands with K i values of 14.5, 43.3 nM for α1a-AR and α1b-AR, respectively [1]. BODIPY FL prazosin (100 nM, 30 min) can be used as molecular probe for the Visualization of the non-adrenoceptor binding site of α1-adrenergic drugs in erythroleukemia cells [3].
Cas No.
175799-93-6
分子式
C28H32BF2N7O3
分子量
563.41
储存和溶解度
(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years