Tipepidine可逆地抑制多巴胺 D2受体介导的GIRK 电流 (IDA(GIRK))，从而激活 VTA 多巴胺神经元， 对 IDA(GIRK)的IC50为 7.0 μM。Tipepidine是一种镇咳药，具有抗抑郁样作用。

Tipepidine reversibly inhibits dopamine (DA) D 2 receptor-mediated GIRK currents (I DA(GIRK) ) with an IC 50 of 7.0 μM. Tipepidine subsequently activates VTA dopamine neuron [1]. Tipepidine, a non-narcotic antitussive, exerts an antidepressant-like effect [2].

Tipepidine (i.p.; 10-40 mg/kg; 0.5-23 hours) significantly decreases the immobility time in the forced swimming test in ACTH-treated rats. Tipepidine (i.p.; 40 mg/kg) increases the extracellular dopamine level of the nucleus accumbens (NAc) in ACTH-treated rats [2]. Animal Model: Male Wistar rats weighting 150-240 g (5-7 weeks old) [2] Dosage: 10, 20 and 40 mg/kg. Administration: I.p.; 0.5, 5, 23 hours. Result: Decreased the immobility time in the forced swimming test in ACTH-treated rats.

5169-78-8

C15H17NS2

275.43

(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years