SP-8356 是一种有效的、口服活性的分化簇 147 (CD147) 抑制剂，具有抗动脉粥样硬化作用。

SP-8356 is a potent, orally active inhibitor of cluster of differentiation 147 (CD147) with anti-atherosclerotic effects.

In a time- and dose-dependent manner, SP-8356 (5-10?μM; 48 hours) inhibits the growth of various types of breast cancer cell lines. SP-8356 (10?μM; 48 hours) increases the percentage of MDA-MB231 cells in the S phase and decreases caspase-3 and cleaved PARP [1].

In a xenograft mouse model, SP-8356 (10?mg/kg; i.p.; every three days until the 42nd day) inhibits tumor growth [1]. SP-8356 (50 mg/kg; p.o.; daily one day after carotid artery ligation for three weeks) prevents the formation of plaque and attenuates its vulnerability [2].

1454885-45-0

C18H20O4

300.35

DMSO:60 mg/ml (199.77 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years