SY-640 是乙酰胺的衍生物,具有强大的保肝作用。
半岛bd体育手机客户端 描述
SY-640 is a derivative of Acetamide showing potent hepatoprotective effects.
体外活性
SY-640 attenuates the increased expression of leukocyte function-associated antigen-1 and inhibits the number of liver-infiltrating cells[1].
体内活性
SY-640 (p.o.; 150 mg/kg; once daily for three days) significantly increases the liver microsomal cytochrome P-450 content and aminopyrine demethylase activity in mice. The hepatic microsomal aminopyrine demethylase activity is obviously inhibited two hours after oral administration of SY-640[1]. SY-640 (oral; 150 mg/kg; once daily for 7 days) significantly inhibits Propionibacterium acnes and Lipopolysaccharide-induced liver injury, but a single administration is without effect[2].
Cas No.
168705-70-2
分子式
C11H13NO3
分子量
207.23
储存和溶解度
DMSO:100 mg/mL (482.56 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years