Endoxifen E-isomer 是一种 Endoxifen 的 E-异构体,是 Endoxifen Z-isomer 原料中主要的杂质。Endoxifen E-isomer 具有抗雌激素活性。
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Endoxifen E-isomer is the E-isomer of (Z)-Endoxifen. Endoxifen E-isomer has antiestrogenic effects.
体外活性
Endoxifen exists as the potently anti-estrogenic (Z)-isomer and the lesser-known (E)-isomer. (E)-Endoxifen is identified as the primary degradant. The (E)-isomer is an impurity in (Z)-Endoxifen drug substance and increases under certain storage conditions.
Cas No.
114828-90-9
分子式
C25H27NO2
分子量
373.49
别名
Endoxifen E-isomer;E-Endoxifen;N-去甲-4-羟基-三苯氧胺
储存和溶解度
DMSO:30 mg/mL (80.32 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years