Sulfathiazole 是一种短效磺胺类抗生素。
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Sulfathiazole, an organosulfur compound, has been served as a short-acting sulfa medicine.
体外活性
Sulfathiazole (20 μg/L) starts to be degraded between day 31 and day 38 in one of the two batch reactors containing different wastewater matrices. Sulfathiazole is degraded at a substantially faster rate than sulfamethoxazole or sulfamethazine in the nitrification process (S3). [1] Recovery from spiked manure slurry samples is 64% for Sulfathiazole at pH 9. Sulfathiazole has acidity constant of pKa of 7.1and retention times (tR) of 7.8. S/N values for Sulfathiazole are above 100 at the 1 mg/kg level. [2] Sulfathiazole sorption to inorganic sorbents exhibits pronounced pH dependence consistent with sorbate speciation and sorbent charge properties. Sulfathiazole cations are most important for sorption to clay minerals, followed by neutral species. [3] Sulfathiazole posseses at least five crystalline or polymorphic forms: I, II, III, IV and V. Although both amido and imido forms are possible for the sulfathiazole molecule, the Sulfathiazole exists in the solid state in the imido form. [4] Sulfathiazole (94.9 mg/L) causes a significant increase in reactive oxygen species (ROS) generation and lipid peroxidation in the presence of ultraviolet B (UV-B) light. Exposure to Sulfathiazole and UV-B light causes apparent up-regulation of alpha-esterase, hemoglobin, and vitellogenin mRNA and significantly affect the survival of daphnids. [5]
Cas No.
72-14-0
分子式
C9H9N3O2S2
分子量
255.32
别名
磺胺噻唑;2-Sulfanilamidothiazole
储存和溶解度
DMSO:48 mg/mL (188 mM)
Ethanol:<1 mgml
Powder: -20°C for 3 years
In solvent: -80°C for 2 years