Urolithin A是一种鞣花酸的肠道微生物代谢产物,可诱导自噬和凋亡,抑制细胞周期进程,抑制DNA合成,具有抗炎、抗增殖和抗氧化的特性。
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Urolithin A is a secondary metabolite of ellagic acid, a polyphenolic antioxidant, that has antiproliferative, anti-inflammatory, and anti-oxidant properties.
体外活性
Urolithin A decreases proliferation in ECC-1, Ishikawa, and HEC-1A human endometrial cancer cell lines at a concentration of 1 μM, arrests the cell cycle at the G2/M transition, and modulates estrogen receptor-regulated gene expression[1].
Cas No.
1143-70-0
分子式
C13H8O4
分子量
228.203
别名
尿石素A;3,8-二羟基-6H-二苯并[B,D]吡喃-6-酮
储存和溶解度
DMSO:33 mg/mL (144.61 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years