N106 是 SUMO 激活酶 E1 连接酶的激活剂，并触发 SERCA2a 的内在 sumoylation。 N106 可用于有关心力衰竭的研究。
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N106 is an activator of the SUMO-activating enzyme, E1 ligase, and triggers intrinsic sumoylation of SERCA2a. N106 can be used in studies about heart failure.
体外活性
N106 (10 min) increases cell contractility, calcium-transient SERCA2a's ATPase activity and SUMOylation. These effects are sustained at 24 h in cardiomyocytes[1].
体内活性
N106 (10 mg/kg) significantly improves ventricular function in mice with heart failure. N106(10 mg/kg; i.v.) exhibits a half-life of 65.4 min and a Cmax of ~2.24 μM[1].
Cas No.
862974-25-2
分子式
C17H14N4O3S
分子量
354.38
别名
N 106;N-106
储存和溶解度
(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years
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