Linarin 是一种选择性的乙酰胆碱酯酶 (AChE) 抑制剂，从薄荷花提取物中分离得到。

1. Linarin (acacetin-7-O-β-d-rutinoside) shows selective dose dependent inhibitory effect on acetylcholinesterase. 2. Linarin alleviates GalN/LPS-induced liver injury by suppressing TNF-α-mediated apoptotic pathways. 3. Linarin prevents A beta-induced neurotoxicity through the activation of PI3K/Akt, which subsequently inhibits GSK-3b and up-regulates Bcl-2. 4. The piperine significantly enhanced the oral absorption of Linarin in rats by inhibiting P-glycoprotein mediated cellular efflux during the intestinal absorption and likely simultaneously by inhibiting the metabolism of Linarin.

480-36-4

C28H32O14

592.55

Acacetin-7-O-rutinoside;Buddleoflavonoloside;Buddleoside;Linarine;蒙花苷;Acaciin

Pyridine, Methanol, etc.:Soluble
DMSO:91 mg/mL(153.6 mM)
Ethanol:Soluble
Powder: -20°C for 3 years
In solvent: -80°C for 2 years