Quinidine hydrochloride 是一种抗心律失常剂,也是 K+通道 (K+channel) 的有效阻断剂,其IC50值为 19.9 μM。它是一种有效且选择性的细胞色素 P450db (cytochrome P450db) 抑制剂,也可用作疟疾的研究。
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Quinidine is an optical isomer of quinine, extracted from the bark of the Cinchona tree and similar plant species. It prolongs cellular action potential and decreases automaticity. This alkaloid dampens the excitability of cardiac and skeletal muscles by blocking sodium and potassium currents across cellular membranes. Quinidine also blocks muscarinic and alpha-adrenergic neurotransmission.
Cas No.
6151-40-2
分子式
C20H27ClN2O3
分子量
378.9
别名
奎尼丁盐酸盐一水合物;Quinidine hydrochloride;奎宁树;奎尼丁盐酸盐
储存和溶解度
DMSO:10 mM
Powder: -20°C for 3 years
In solvent: -80°C for 2 years