Hydroxyprogesterone 是一种内源性孕激素，其他类固醇激素（包括糖皮质激素，雌激素，和雄激素）生物合成的化学中间体。

Hydroxyprogesterone is a physiological progestin that is produced during glucocorticoid and steroid hormone synthesis and is increased during the third trimester of pregnancy. Hydroxyprogesterone binds to the cytoplasmic progesterone receptors in the reproductive system and subsequently activates progesterone receptor-mediated gene expression.

17α-OHP is an agonist of the progesterone receptor (PR) similarly to progesterone, albeit weakly in comparison[1]. It is a chemical intermediate in the biosynthesis of steroid hormones, including the androgen and estrogen sex hormones and the glucocorticoids and mineralocorticoids.

17-Hydroxyprogesterone is a potent steroid inducer of GVBD (germinal vesicle breakdown)[3].

68-96-2

C21H30O3

330.47

Hydroxyprogesterone;17-Hydroxyprogesterone;17-OHP;17α-羟孕酮;羟孕酮

DMSO:38 mg/mL (115 mM)
Ethanol:61 mg/mL (184.6 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years