Isoginkgetin 是一种MMP9抑制剂，也是一种Pre-mRNA Splicing抑制剂。

1. Isoginkgetin, a compound derived from the leaves of Ginkgo biloba, to up-regulate adiponectin secretion with potency comparable to that of rosiglitazone, a known modulator of adiponectin production. 2. Isoginkgetin has anti-tumor activity, the mechanistic basis is splicing inhibition , thus, pre-mRNA splicing inhibitors may represent a novel avenue for development of new anti-cancer agents.3. Isoginkgetin can inhibit tumor cell invasion by regulating phosphatidylinositol 3-kinase/Akt-dependent matrix metalloproteinase-9 expression. 4. Isoginkgetin (0.3mg/kg ip for 3d) can reduce the level of O2·- in plasma and erythroeyte and sometimes increase the activity of SOD in anoxic rats, the action being stronger than aspirin.

548-19-6

C32H22O10

566.518

异银杏素;异银杏双黄酮;4',4'''-Dimethylamentoflavone

DMSO:83.3 mg/mL (147.04 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years