GRP-60367 hydrochloride - 半岛电竞官方网址

您好，欢迎来到半岛电竞官方网址！ [ 登录] [ 免费注册]

立即咨询

咨询类型：

采购售后

*姓名：

*电话：

*单位：

Email：

*留言内容：

请详细说明您的需求。

*验证码：

GRP-60367 hydrochloride

本半岛bd体育手机客户端不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

包装与价格：

半岛bd体育手机客户端介绍

GRP-60367hydrochloride是种首创的小分子狂犬病病毒(RABV)进入抑制剂，对某些RABV株具有纳摩尔作用效果。GRP-60367hydrochloride特异性靶向RABVG蛋白。

Canonical SMILES	CC1=C(OCCNC2CCN(C(C3=CC=NC=C3)=O)CC2)C=C(C)C=C1.[H]Cl
分子式	C₂₁H₂₈ClN₃O₂
分子量	389.92
溶解度	DMSO: 250 mg/mL (641.16 mM)
储存条件	Store at -20℃
General tips	For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping Condition	Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request
半岛bd体育手机客户端描述	GRP-60367 hydrochloride is a first-in-class small-molecule rabies virus (RABV) entry inhibitor with nanomolar potency against some RABV strains. GRP-60367 hydrochloride specifically targets the RABV G protein[1]. GRP-60367 (0.1 nM-1000 μM) confirms specific and potent anti-RABV activity of the scaffold, returning in dose-response assays EC50s ranging from 2 to 52 nM on different host cell lines[1]. Cell Viability Assay[1] Cell Line: BEAS-2B, 293T, or Hep-2 cell lines [1]. Venice Du Pont, et al. Identification and Characterization of a Small-Molecule Rabies Virus Entry Inhibitor. J Virol. 2020 Jun 16;94(13):e00321-20.