Chebulagic acid是从 Terminalia chebula Retz 中分离出来的一种COX-LOX双重抑制剂，有抗炎和抗感染作用。它抑制SARS-CoV-2病毒的复制，EC50值为 9.76 μM。它还是M2(S31N)抑制剂和抗流感病毒剂。

Chebulagic acid, isolated from the Terminalia chebula Retz, is a COX-LOX dual inhibitor.

Chebulagic acid can enhance autophagy and exerts anti-inflammatory and anti-infective effects [1,2]. Chebulagic acid also shows a protective effect against 1-methyl-4-phenylpyridinium (MPP+) - induce cytotoxicity which mimics the pathological symptom of Parkinson's disease. Chebulagic acid inhibits the LPS-induced upregulation of TNF-α and IL-1β in a dose- and time-dependent manner [3].

23094-71-5

C41H30O27

954.66

DMSO:98 mg/mL (102.66 mM),Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years