Mal-PEG4-acid是一种基于PEG的PROTAClinker,可用于PROTAC的合成。
Cas No. |
518044-41-2 |
别名 |
马来酰亚胺-四聚乙二醇-羧酸 |
Canonical SMILES |
O=C(O)CCOCCOCCOCCOCCN1C(C=CC1=O)=O |
分子式 |
C15H23NO8 |
分子量 |
345.35 |
溶解度 |
DMSO: 100 mg/mL (289.56 mM) |
储存条件 |
-20°C, protect from light |
General tips |
For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
Shipping Condition |
Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
半岛bd体育手机客户端 描述 |
Mal-PEG4-acid is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein.PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins. |