Mal-PEG8-acid是一种基于PEG结构的PROTAClinker,可用于PROTAC的合成。
Cas No. |
1818294-46-0 |
别名 |
马来酰亚胺基-PEG8-丙酸 |
Canonical SMILES |
O=C(O)CCOCCOCCOCCOCCOCCOCCOCCOCCN1C(C=CC1=O)=O |
分子式 |
C23H39NO12 |
分子量 |
521.56 |
溶解度 |
DMSO: 100 mg/mL (191.73 mM) |
储存条件 |
-20°C, protect from light |
General tips |
For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
Shipping Condition |
Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
半岛bd体育手机客户端 描述 |
Mal-PEG8-acid is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein.PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins. |