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Propargyl-PEG2-acid

本半岛bd体育手机客户端不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

1859379-85-3

包装与价格：

半岛bd体育手机客户端介绍

Propargyl-PEG2-acid是一种不可降解(non-cleavable)的含2个单元PEG的ADClinker，可用于合成抗体偶联药物(ADC)。Propargyl-PEG2-acid还是一种PROTAClinker，属于PEG类，可用于合成PROTAC分子。

Cas No.	1859379-85-3
别名	丙炔-单乙二醇-丙酸
Canonical SMILES	O=C(O)CCOCCOCC#C
分子式	C₈H₁₂O₄
分子量	172.18
溶解度	DMSO: 250 mg/mL (1451.97 mM)
储存条件	4℃, stored under nitrogen
General tips	For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping Condition	Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request
半岛bd体育手机客户端描述	Propargyl-PEG2-acid is a non-cleavable 2 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Propargyl-PEG2-acid is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[1].PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1]. [1]. Sano K, et al. Short PEG-linkers improve the performance of targeted, activatable monoclonal antibody-indocyanine green optical imaging probes. Bioconjug Chem. 2013 May 15;24(5):811-6.