Azido-PEG8-amine 是一种 PROTAC linker,属于 PEG 类。可用于合成 PROTAC 分子。
Cas No. |
857891-82-8 |
别名 |
O-(2-氨基乙基)-O′-(2-叠氮乙基)七聚乙二醇 |
分子式 |
C18H38N4O8 |
分子量 |
438.52 |
储存条件 |
4°C, protect from light |
General tips |
For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
Shipping Condition |
Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
半岛bd体育手机客户端 描述 |
Azido-PEG8-amine is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1]. [1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 |