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Tris[[2-(tert-butoxycarbonyl)ethoxy]methyl]methylamine
本半岛bd体育手机客户端 不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
Tris[[2-(tert-butoxycarbonyl)ethoxy]methyl]methylamine图片
CAS NO: 175724-30-8
包装: 50mg
市场价: 450元

半岛bd体育手机客户端 介绍
Tris[[2-(tert-butoxycarbonyl)ethoxy]methyl]methylamine 是一种可降解 (cleavable) 的 PEG 的 ADC linker，可用于合成抗体偶联药物 (ADC)。Tris[[2-(tert-butoxycarbonyl)ethoxy]methyl]methylamine 也是一种 PROTAC linker，属于 PEG 和 Alkyl/ether 类，可用于合成 PROTAC 分子。
Cas No. 175724-30-8
分子式 C25H47NO9
分子量 505.64
储存条件 4°C, protect from light
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping Condition Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
半岛bd体育手机客户端 描述

Tris[[2-(tert-butoxycarbonyl)ethoxy]methyl]methylamine is a cleavable PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Amino-Tri-(t-butoxycarbonylethoxymethyl)-methane is also a PEG/Alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs[1].

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[1].PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

[1]. Kostiainen MA, et al. Optically degradable dendrons for temporary adhesion of proteins to DNA. Chemistry. 2010 Jun 18;16(23):6912-8.
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