您好，欢迎来到半岛电竞官方网址 ！ [ 登录] [ 免费注册]
半岛电竞官方网址
发布求购
位置： 首页> 半岛bd体育手机客户端 库> type II collagen fragment
立即咨询
咨询类型：
*姓名：
*电话：
*单位：
Email：
*留言内容：
请详细说明您的需求。
*验证码：
type II collagen fragment
本半岛bd体育手机客户端 不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
type II collagen fragment图片
包装与价格：
包装 价格(元)
1mg 电议
5mg 电议
10mg 电议
25mg 电议

半岛bd体育手机客户端 介绍

Specific for cartilaginous tissues

别名 H2N-Gly-Glu-Pro-Gly-Ile-Ala-Gly-Phe-Lys-Gly-Glu-Gln-Gly-Pro-Lys-OH
Canonical SMILES NCC(NC(CCC(O)=O)C(N1CCCC1C(NCC(NC(C(C)CC)C(NC(C)C(NCC(NC(CC2=CC=CC=C2)C(NC(CCCCN)C(NCC(NC(CCC(O)=O)C(NC(CCC(N)=O)C(NCC(N3C(C(NC(CCCCN)C(O)=O)=O)CCC3)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O
分子式 C65H102N18O21
分子量 1471.61
溶解度 ≥ 147.1mg/mL in DMSO
储存条件 Store at -20℃
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping Condition Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
半岛bd体育手机客户端 描述

Type II collagen is composed of a triple helix of three identical α chains. These molecules associate to form a fibril that is stabilized by intermolecular crosslinks1. Damage to the fibrillar meshwork, made up of primarily type II collagen (z 90–95%), may be a critical event in the pathology of many arthritides, due in part to the very slow rate of collagen turnover within the cartilage2.

Type II collagen and aggrecan (a large, aggregating proteoglycan) are the two major components of the extracellular matrix of cartilage. The collagen, which is present in a fibrillar form, provides tensile strength whereas the aggrecan is responsible for compressive stiffness of cartilage3-5. Early damage to type II collagen is predominantly pericellular/ territorial suggests that in the majority of cases collagen damage was mediated by the chondrocyte.

References:
1.Eyre, D.R. 1987. Collagen cross-linking amino acids. Methods Enzymol. 144:115–139.
2.McAnulty, R.J., and G.J. Laurent. 1990. In vivo measurement of collagen metabolism in cartilage and bone. In Methods in Cartilage Research. A. Maroudas and K. Kuettner, editors. Academic Press Inc., San Diego, CA. 140–142.
3.Kempson, G. 1980. The mechanical properties ofarticular cartilage. In The Joints and Synovial Fluid. Volume 2. L. Sokoloff, editor. Academic Press Inc.,New York. 238-239.
4.Schmidt, M. B., V. C. Mow, L. E. Chun, and D. R. Eyre. 1990. Effects of proteoglycan extraction on the tensile behaviour ofarticular cartilage. J. Orthop. Res. 8:353-363.
5.Poole, A. R. 1993. Cartilage in health and disease. In Arthritis and Allied Conditions: A Textbook of Rheumatology. D. J. McCarty and W. J. Koopman, editors. Lea & Febiger, Philadelphia. 279-333.
Baidu
map