| CAS NO: | 78281-72-8 |
| 包装 | 价格(元) |
| 10mM (in 1mL DMSO) | 电议 |
| 25mg | 电议 |
| 100mg | 电议 |
| Cas No. | 78281-72-8 |
| 别名 | 奈帕芬胺; AHR 9434; AL 6515 |
| 化学名 | 2-(2-amino-3-benzoylphenyl)acetamide |
| Canonical SMILES | C1=CC=C(C=C1)C(=O)C2=C(C(=CC=C2)CC(=O)N)N |
| 分子式 | C15H14N2O2 |
| 分子量 | 254.28 |
| 溶解度 | ≥ 9.95mg/mL in DMSO |
| 储存条件 | Store at -20℃ |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
| 半岛bd体育手机客户端 描述 | Nepafenac is a non-steroidal anti-inflammatory drug (NSAID). The IC50 values of nepafenac for (cyclooxygenase-1) COX-1 and COX-2 are 250 nM and 150 nM, respectively [1]. Nepafenac showed to significantly decrease the retinal levels of PGE2 in LPS-induced rats when administrated topically. However, nepafenac has revealed no significant effect on BRB permeability in LPS-induced rat model [1]. Nepafenac significantly reduced proliferation rate of human uveal melanoma cell lines including SP6.5, 92.1, OCM-1, MKT-BR and of human transformed uveal melanocyte cell line UW-1. Compared to rofecoxib, nepafenac might reveal a better systemic safety profile [2]. References: |
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