Acetylcholinesterase inhibitor
Cas No. |
1953-04-4 |
别名 |
氢溴酸加兰他敏 |
化学名 |
(4aS,6R,8aS)-3-methoxy-11-methyl-5,6,9,10,11,12-hexahydro-4aH-benzo[2,3]benzofuro[4,3-cd]azepin-6-ol hydrobromide |
Canonical SMILES |
COC1=CC=C2C3=C1O[C@]4([H])[C@]3(C=C[C@H](O)C4)CCN(C)C2.Br |
分子式 |
C17H21NO3.HBr |
分子量 |
368.27 |
溶解度 |
≥ 4.6 mg/mL in DMSO, ≥ 36.9 mg/mL in Water with ultrasonic and warming |
储存条件 |
Store at -20℃ |
General tips |
For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
Shipping Condition |
Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
半岛bd体育手机客户端 描述 |
Long-acting, centrally active acetylcholinesterase inhibitor (IC50 = 410 nM) and allosteric potentiator at neuronal nicotinic ACh receptors. Prevents β-amyloid-induced apoptosis in SH-SY5Y and bovine chromaffin cells. Long-term administration reduces amyl |