PD 166793 是一种有效的、选择性的、具有口服活性的广谱 MMP 抑制剂，对 MMP-2、MMP-3 和 MMP-13 表现出纳摩尔效力（IC50 分别为 4、7 和 8 nM）和微摩尔效力与 MMP-1、-7 和 -9 相比（IC50 分别为 6.0、7.2 和 7.9 μM）。
| Cas No. |
199850-67-4 |
| 别名 |
N-[(4'-溴[1,1'-联苯]-4-基)磺酰基]-L-缬氨酸 |
| 化学名 |
(2S)-2-[[4-(4-bromophenyl)phenyl]sulfonylamino]-3-methylbutanoic acid |
| Canonical SMILES |
CC(C)C(C(=O)O)NS(=O)(=O)C1=CC=C(C=C1)C2=CC=C(C=C2)Br |
| 分子式 |
C17H18BrNO4S |
| 分子量 |
412.3 |
| 溶解度 |
DMF: 50 mg/ml,DMSO: 50 mg/ml,DMSO:PBS (pH 7.2) (1:1): 0.5 mg/ml,Ethanol: 10 mg/ml |
| 储存条件 |
Desiccate at 4℃ |
| General tips |
For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition |
Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
| 半岛bd体育手机客户端 描述 |
Broad spectrum MMP inhibitor. Displays high affinity for MMP-2, -3 and -13 (IC50values are 4, 7 and 8 nM respectively) and exhibits > 750-fold selectivity over MMP-1, -7 and -9. Attenuates left ventricular remodelling and dysfunction in rat model of heart failure. |
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