Mal-NH-PEG8-Boc 是一种 PROTAC linker，属于 PEG 类。可用于合成 PROTAC 分子。
| 分子式 |
C30H52N2O13 |
| 分子量 |
648.74 |
| 溶解度 |
DMSO : 500 mg/mL (770.72 mM; Need ultrasonic) |
| 储存条件 |
4°C, stored under nitrogen |
| General tips |
For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition |
Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
| 半岛bd体育手机客户端 描述 |
Mal-NH-PEG8-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1]. [1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 |
m.cnreagent.com
