ELN318463 racemate 是 ELN318463 的外消旋体，ELN318463 是一种淀粉样前体蛋白 (APP) 选择性 γ-分泌酶抑制剂。
半岛bd体育手机客户端 描述
ELN318463 racemate is the racemate of ELN318463 which is an amyloid precursor protein (APP) selective γ-secretase inhibitor.
体外活性
ELN318463 shows differential inhibition of presenilin (PS1)- and PS2-comprised γ-secretase with EC50s of 12nM and 656 nM for PS1and PS2, respectively[1].
体内活性
Brain levels of ELN318463 (30 mg/kg) are 0.754 μM in FVB brains and 0.69 μM, and of ELN318463(100 mg/kg) are 2.7 μM in FVB brains and 1.87 μM in PDAPP brains[1].
Cas No.
851599-82-1
分子式
C19H20BrClN2O3S
分子量
471.8
别名
ELN318463 (racemate);ELN 318463 racemate
储存和溶解度
(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years
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